CBD Sources

Vincenzo Di Marzo Maurizio Bifulco & Luciano De Petrocellis  The endocannabinoid system and its therapeutic exploitation, Nature Reviews Drug Discovery, 771-784 (September 2004) | doi:10.1038/nrd1495
Silvia Conti, Barbara Costa, Mariapia Colleoni, Daniela Parolaro, Gabriella Giagnoni Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat, British Journal of Pharmacology, January 2002
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202504 Natalya M. Kogan, MSc, Raphael Mechoulam, Ph.D, Cannabinoids in Health and Disease, Diaglogues Clin Neurosci, 2007 Dec; 9(4): 413–430.
Fiona A Campbell, Martin R Tramèr, Dawn Carroll, D John M Reynolds,  R Andrew Moore, Henry J McQuay. Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. BMJ 2001; 323 doi: https://doi.org/10.1136/bmj.323.7303.13 (Published 07 July 2001)  Cite this as: BMJ 2001; 323:13
Mary E. Lynch, Fiona CampbellCannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials British Journal of Clinical Pharmacology, 11 October 2011, DOI: 10.1111/j.1365-2125.2011.03970.x http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2011.03970.x/full
University of Bonn. “Cannabis reverses aging processes in the brain, study suggests: Researchers restore the memory performance of Methuselah mice to a juvenile stage.” ScienceDaily. ScienceDaily, 8 May 2017.
Di Marzo, The endocannabinoid system in obesity and type 2 diabetes.  Diabetologia.  2008 Aug;51(8):1356-67. doi: 10.1007/s00125-008-1048-2. Epub 2008 Jun 18. https://link.springer.com/article/10.1007/s00125-008-1048-2
Aviello G, Romano B, Izzo AA, Cannabinoids and gastrointestinal motility: animal and human studies.  Eur Rev Med Pharmacol Sci.  2008 Aug;12 Suppl 1:81-93. https://www.ncbi.nlm.nih.gov/pubmed/18924447
TamásBíró 1 Balázs I.Tóth 1 GyörgyHaskó 2 RalfPaus 34 PálPacher 5 , The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities  Trends in Pharmacological Sciences;  Volume 30, Issue 8 , August 2009, Pages 411-420 https://doi.org/10.1016/j.tips.2009.05.004  h ttp://www.sciencedirect.com/science/article/pii/S0165614709001072

Ethan B Russo Cannabinoids in the management of difficult to treat pain; Ther Clin Risk Manag. 2008 Feb; 4(1): 245–259. Published online 2008 Feb. PMCID: PMC2503660 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/

Sabine Steffens, Niels R. Veillard, Claire Arnaud, Graziano Pelli, Fabienne Burger, Christian Staub, Andreas Zimmer, Jean-Louis Frossard & François Mach, Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice; Nature 434, 782-786 (7 April 2005) | doi:10.1038/nature03389; Received 26 October 2004; Accepted 21 January 2005.https://www.nature.com/nature/journal/v434/n7034/full/nature03389.html

ProfLuc FVan GaalaAila MRissanenbAndré JScheencOlivierZieglerdStephanRössnerefor the RIO-Europe Study Group; Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study; The Lancet; Volume 365, Issue 9468, 16-22 April 2005, Pages 1389-1397 http://www.sciencedirect.com/science/article/pii/S014067360566374X

Babson KA, Sottile J, Morabito D.. Cannabinoids, and Sleep: a Review of the Literature. Curr Psychiatry Rep. 2017. Apr;19(4):23. doi: 10.1007/s11920-017-0775-9.https://www.ncbi.nlm.nih.gov/pubmed/28349316

J Manzanares, MD Julian, A Carrascosa. Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes Curr Neuropharmacol. 2006 Jul; 4(3): 239–257. PMCID: PMC2430692. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/

NIHMSID: NIHMS478219    Thomas F. Gamage , BS and   Aron H. Lichtman , PhD ;  The Endocannabinoid System: Role in Energy Regulation  Pediatr Blood Cancer. 2012 Jan; 58(1): 144–148.    Pediatr Blood Cancer . available in PMC 2013 Jun 30. doi:   10.1002/pbc.23367  PMCID: PMC3696506   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696506/
Bénard GMassa FPuente NLourenço JBellocchio LSoria-Gómez EMatias IDelamarre AMetna-Laurent MCannich AHebert-Chatelain EMulle COrtega-Gutiérrez SMartín-Fontecha MKlugmann MGuggenhuber SLutz BGertsch JChaouloff FLópez-Rodríguez MLGrandes PRossignol RMarsicano GNat Neurosci. Mitochondrial CB₁ receptors regulate neuronal energy metabolism.  Nat Neurosci. 2012 Mar 4;15(4):558-64. doi: 10.1038/nn.3053. https://www.ncbi.nlm.nih.gov/pubmed/22388959
Béla Horváth Partha Mukhopadhyay ,   György Haskó ,   Pál Pacher ;  The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications. The American Journal of Pathology. . 2012 Feb; 180(2): 432–442.  doi:   10.1016/j.ajpath.2011.11.003   PMCID: PMC3349875. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349875/
Vincenzo Di MarzoMaurizio BifulcoLuciano De Petrocellis  The endocannabinoid system and its therapeutic exploitation, Nature Reviews Drug Discovery 3, 771–784(2004) doi:10.1038/nrd1495  https://www.nature.com/articles/nrd1495#auth-1
Oreja-Guevara, Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity.  Expert Rev Neurother. 2012 Apr;12(4 Suppl):3-8. doi: 10.1586/ern.12.11.  http://www.ncbi.nlm.nih.gov/pubmed/22509985
Nora D. Volkow, Director, The Biology and Potential Therapeutic Effects of Cannabidiol; National Institute on Drug Abuse. Senate Caucus on International Narcotics Control; June 24, 2015
Ethan B. Russo, Cannabinoids in the management of difficult to treat pain.  Ther Clin Risk Manag . 2008 Feb; 4(1): 245–259.  Published online 2008 Feb.  PMCID: PMC2503660 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
Ward SJMcAllister SDKawamura RMurase RNeelakantan HWalker EA ,  Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy.  Br J Pharmacol, 2014 Feb; 171(3):636-45. Doi: 10.1111/bph.12439.  http://www.ncbi.nlm.gov/pubmid/?term=Br+J+Pharmacol+2014+Feb%38171(3)%3A636-45.+doi%3A+10.1111%2Fbph.12439
Alexander Neumeister , M.D., Marc D. Normandin , Ph.D.,  Robert H. Pietrzak , Ph.D., M.P.H.,  Daniele Piomelli , Ph.D.,  Ming-Qiang Zheng , Ph.D.,   Ana Gujarro-Anton , PhD.,  Marc N. Potenza , M.D., Ph.D.,  Christopher R. Bailey , B.A.,  Shu-fei Lin , Ph.D.,  Soheila Najafzadeh , M.S.,  Jim Ropchan , Ph.D.,  Shannan Henry , B.S.,  Stefani Corsi-Travali , B.A.,  Richard E. Carson , Ph.D., and   Yiyun Huang , Ph.D.; Elevated Brain Cannabinoid CB 1  Receptor Availability in Posttraumatic Stress Disorder: A Positron Emission Tomography Study  Mol Psychiatry. 2013 Sep; 18(9): 1034–1040.   Published online 2013 May 14. doi:   10.1038/mp.2013.61  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752332/   
Rajesh MMukhopadhyay PBátkai SPatel VSaito KMatsumoto SKashiwaya YHorváth BMukhopadhyay BBecker LHaskó GLiaudet LWink DAVeves AMechoulam RPacher P . Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.  J Am Coll Cardiol.  2010 Dec 14;56(25):2115-25. doi: 10.1016/j.jacc.2010.07.033.  https://www.ncbi.nlm.nih.gov/pubmed/21144973
Jeremy R.JohnsonMB ChB a MaryBurnell-NugentMB BChir b DominiqueLossignolMB ChB, MRCG, DRCOG c Elena DoinaGanae-MotanMD d RichardPottsBSc (Hons), MICR e Marie T.FallonMB ChB, MD, FRCP (E), FRCP (Glasg) f   Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain  J Am Coll Cardiol.  2010 Dec 14;56(25):2115-25. doi: 10.1016/j.jacc.2010.07.033.  http://www.sciencedirect.com/science/article/pii/S0885392409007878
Josée Guindon, Andrea G Hohmann The endocannabinoid system and cancer: therapeutic implication British Journal of Pharmacology First published: 12 July 2011  http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01327.x/full
Blessing EM Steenkamp MM Manzanares J Marmar CR . Cannabidiol as a Potential Treatment for Anxiety Disorders.  Neurotherapeutics.  2015 Oct;12(4):825-36. doi: 10.1007/s13311-015-0387-1.  https://www.ncbi.nlm.nih.gov/pubmed/26341731
El-Alfy, Abir T, et al, “Indirect modulation of the endocannabinoid system by specific fractions of nutmeg total extract,” Pharmaceutical Biology, 2016.
John M. McPartlandGeoffrey W. GuyVincenzo Di Marzo; Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System PLoS One. 2014; 9(3): e89566. Published online 2014 Mar 12. doi:  10.1371/journal.pone.0089566
Nora D. Volkow, Director, National Institute on Drug Abuse Senate Caucus on International Narcotics Control Testimony to Congress, The Biology and Potential Therapeutic Effects of Cannabidiol;  June 24, 2015
Nandini Acharya, Sasi Peukonda, Tatiana Shcheglove, Adam Hagymasi, Sreyashi Basu, Pramod Srivastava. Endocannabinoid system acts as a regulator of immune homeostasis in the gut, Proceedings of the Natioanl Academy of Sciences of the United States of America. March 27, 2017, vol. 114 no. 19 5005–5010, doi: 10.1073/pnas.1612177114
García C, Palomo-Garo C, García-Arencibia M, Ramos J, Pertwee R, Fernández-Ruiz J. Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson’s disease. British Journal of Pharmacology. 2011;163(7):1495-1506. doi:10.1111/j.1476-5381.2011.01278.x.
Martín-Moreno AM, Reigada D, Ramírez BG, et al. Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease. Molecular Pharmacology. 2011;79(6):964-973. doi:10.1124/mol.111.071290.
Das RK, Kamboj SK, Ramadas M, Yogan K, Gupta V, Redman E, Curran HV, Morgan CJ. Cannabidiol enhances consolidation of explicit fear extinction in humans.
Psychopharmacology (Berl). 2013 Apr;226(4):781-92. doi: 10.1007/s00213-012-2955-y. Epub 2013 Jan 10
Neelakantan H, Tallarida RJ, Reichenbach ZW, Tuma RF, Ward SJ, Walker EA. Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.
Behav Pharmacol. 2015 Apr;26(3):304-14
Xiong W, Cui T, Cheng K, Yang F, Chen SR, Willenbring D, Guan Y, Pan HL, Ren K, Xu Y, Zhang L.Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med. 2012 Jun 4;209(6):1121-34. doi: 10.1084/jem.20120242. Epub 2012 May 14.
Bergamaschi MM, Queiroz RH, Chagas MH, de Oliveira DC, De Martinis BS, Kapczinski F, Quevedo J, Roesler R, Schröder N, Nardi AE, Martín-Santos R, Hallak JE, Zuardi AW, Crippa JA. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 2011 May;36(6):1219-26.
Chakravarti B, Ravi J, Ganju RK. Cannabinoids as therapeutic agents in cancer: current status and future implications. Oncotarget. 2014;5(15):5852-5872.

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