CBD Sources – Citations

  1. Vincenzo Di Marzo Maurizio Bifulco & Luciano De Petrocellis  The endocannabinoid system and its therapeutic exploitation, Nature Reviews Drug Discovery, 771-784 (September 2004) | doi:10.1038/nrd1495
  2. Silvia Conti, Barbara Costa, Mariapia Colleoni, Daniela Parolaro, Gabriella Giagnoni Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat, British Journal of Pharmacology, January 2002
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202504 Natalya M. Kogan, MSc, Raphael Mechoulam, Ph.D, Cannabinoids in Health and Disease, Diaglogues Clin Neurosci, 2007 Dec; 9(4): 413–430. 
  4. Fiona A Campbell, Martin R Tramèr, Dawn Carroll, D John M Reynolds,  R Andrew Moore, Henry J McQuay. Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. BMJ 2001323 doi: https://doi.org/10.1136/bmj.323.7303.13 (Published 07 July 2001) Cite this as: BMJ 2001; 323:13
  5. Mary E. Lynch, Fiona CampbellCannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials British Journal of Clinical Pharmacology, 11 October 2011, DOI: 10.1111/j.1365-2125.2011.03970.x   http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2011.03970.x/full
  6. University of Bonn. “Cannabis reverses aging processes in the brain, study suggests: Researchers restore the memory performance of Methuselah mice to a juvenile stage.” ScienceDaily. ScienceDaily, 8 May 2017. <www.sciencedaily.com/releases/2017/05/170508112400.htm>
  7. Di Marzo, The endocannabinoid system in obesity and type 2 diabetes. Diabetologia. 2008 Aug;51(8):1356-67. doi: 10.1007/s00125-008-1048-2. Epub 2008 Jun 18. https://link.springer.com/article/10.1007/s00125-008-1048-2
  8. Aviello G, Romano B, Izzo AA, Cannabinoids and gastrointestinal motility: animal and human studies. Eur Rev Med Pharmacol Sci. 2008 Aug;12 Suppl 1:81-93. https://www.ncbi.nlm.nih.gov/pubmed/18924447
  9. TamásBíró1Balázs I.Tóth1GyörgyHaskó2RalfPaus34PálPacher5, The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities Trends in Pharmacological Sciences; Volume 30, Issue 8, August 2009, Pages 411-420 https://doi.org/10.1016/j.tips.2009.05.004 http://www.sciencedirect.com/science/article/pii/S0165614709001072
  10. Ethan B Russo Cannabinoids in the management of difficult to treat pain; Ther Clin Risk Manag. 2008 Feb; 4(1): 245–259. Published online 2008 Feb.  PMCID: PMC2503660  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
  11. Sabine Steffens, Niels R. Veillard, Claire Arnaud, Graziano Pelli, Fabienne Burger, Christian Staub, Andreas Zimmer, Jean-Louis Frossard & François Mach, Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice; Nature 434, 782-786 (7 April 2005) | doi:10.1038/nature03389; Received 26 October 2004; Accepted 21 January 2005.https://www.nature.com/nature/journal/v434/n7034/full/nature03389.html
  12. ProfLuc FVan GaalaAila MRissanenbAndré JScheencOlivierZieglerdStephanRössnerefor the RIO-Europe Study Group; Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study; The Lancet; Volume 365, Issue 9468, 16-22 April 2005, Pages 1389-1397  http://www.sciencedirect.com/science/article/pii/S014067360566374X
  13. S.JohnGatleyaAndrew N.GiffordaNora D.VolkowaRuoxiLanb  I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors   European Journal of Pharmacology; Volume 307, Issue 3, 4 July 1996, Pages 331-338 https://doi.org/10.1016/0014-2999(96)00279-8  http://www.sciencedirect.com/science/article/pii/0014299996002798
  14. Babson KASottile JMorabito D.. Cannabinoids, and Sleep: a Review of the Literature. Curr Psychiatry Rep. 2017. Apr;19(4):23. doi: 10.1007/s11920-017-0775-9.https://www.ncbi.nlm.nih.gov/pubmed/28349316
  15. J Manzanares, MD Julian, A Carrascosa. Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes  Curr Neuropharmacol. 2006 Jul; 4(3): 239–257.   PMCID: PMC2430692. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/
  16. NIHMSID: NIHMS478219   Thomas F. Gamage, BS and  Aron H. Lichtman, PhD; The Endocannabinoid System: Role in Energy Regulation Pediatr Blood Cancer. 2012 Jan; 58(1): 144–148.  Pediatr Blood Cancer. available in PMC 2013 Jun 30. doi:  10.1002/pbc.23367 PMCID: PMC3696506  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696506/
  17. Hil, Matthew N.Gorzalka, Boris B. The Endocannabinoid System and the Treatment of Mood and Anxiety DisordersCNS & Neurological Disorders – Drug Targets (Formerly Current Drug Targets – CNS & Neurological Disorders), Volume 8, Number 6, December 2009, pp. 451-458(8).  Bentham Science Publishers   https://doi.org/10.2174/187152709789824624, Ingenta Connect  http://www.ingentaconnect.com/content/ben/cnsnddt/2009/00000008/00000006/art00006
  18. Bénard G, Massa FPuente NLourenço JBellocchio LSoria-Gómez EMatias IDelamarre AMetna-Laurent MCannich AHebert-Chatelain EMulle COrtega-Gutiérrez SMartín-Fontecha MKlugmann MGuggenhuber SLutz BGertsch JChaouloff FLópez-Rodríguez MLGrandes PRossignol RMarsicano G. Nat Neurosci. Mitochondrial CB₁ receptors regulate neuronal energy metabolism.  Nat Neurosci. 2012 Mar 4;15(4):558-64. doi: 10.1038/nn.3053. https://www.ncbi.nlm.nih.gov/pubmed/22388959
  19. Béla HorváthPartha Mukhopadhyay, György Haskó,  Pál Pacher; The Endocannabinoid System and Plant-DerivedCannabinoids in Diabetes and Diabetic Complications. The American Journal of Pathology. . 2012 Feb; 180(2): 432–442. doi:  10.1016/j.ajpath.2011.11.003  PMCID: PMC3349875. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349875/
  20. Vincenzo Di MarzoMaurizio BifulcoLuciano De Petrocellis The endocannabinoid system and its therapeutic exploitation, Nature Reviews Drug Discovery 3, 771–784(2004) doi:10.1038/nrd1495 https://www.nature.com/articles/nrd1495#auth-1
  21. Ethan B. Russo, Plants and the Endo-cannabinoid System.  Trends in Pharmacological Sciences, TIPS 1329 No. of Pages 12.http://mychronicrelief.com/cannabis-science/endocannabinoid-system-ecs/http://mychronicrelief.com/wp-content/uploads/2016/05/Beyond-Cannabis-Plants-and-the-Endocannabinoid-System.pdf
  22. https://www.cbd.org/sites/cbd/files/downloads/cbdpatientsurvery_september2015_carebydesign.pdf 
  23. Oreja-Guevara, Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity. Expert Rev Neurother.2012 Apr;12(4 Suppl):3-8. doi: 10.1586/ern.12.11. http://www.ncbi.nlm.nih.gov/pubmed/22509985
  24. Nora D. Volkow, Director, The Biology and Potential Therapeutic Effects of Cannabidiol; National Institute on Drug Abuse. Senate Caucus on International Narcotics Control; June 24, 2015
  25. Ethan B. Russo, Cannabinoids in the management of difficult to treat pain. Ther Clin Risk Manag. 2008 Feb; 4(1): 245–259.  Published online 2008 Feb.  PMCID: PMC2503660https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
  26. Ward SJMcAllister SDKawamura RMurase RNeelakantan HWalker EA, Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy. Br J Pharmacol, 2014 Feb; 171(3):636-45. Doi: 10.1111/bph.12439. http://www.ncbi.nlm.gov/pubmid/?term=Br+J+Pharmacol+2014+Feb%38171(3)%3A636-45.+doi%3A+10.1111%2Fbph.12439
  27. Alexander Neumeister, M.D.,Marc D. Normandin, Ph.D., Robert H. Pietrzak, Ph.D., M.P.H., Daniele Piomelli, Ph.D., Ming-Qiang Zheng, Ph.D., Ana Gujarro-Anton, PhD., Marc N. Potenza, M.D., Ph.D., Christopher R. Bailey, B.A., Shu-fei Lin, Ph.D., Soheila Najafzadeh, M.S., Jim Ropchan, Ph.D., Shannan Henry, B.S., Stefani Corsi-Travali, B.A., Richard E. Carson, Ph.D., and  Yiyun Huang, Ph.D.; Elevated Brain Cannabinoid CB1 Receptor Availability in Posttraumatic Stress Disorder: A Positron Emission Tomography Study Mol Psychiatry. 2013 Sep; 18(9): 1034–1040.  Published online 2013 May 14. doi:  10.1038/mp.2013.61 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752332/   
  28. https://www.projectcbd.org/sites/projectcbd/files/downloads/ptsd-patient-survey_2016_march.pdf
  29. Rajesh MMukhopadhyay PBátkai SPatel VSaito KMatsumoto SKashiwaya YHorváth BMukhopadhyay BBecker LHaskó GLiaudet LWink DAVeves AMechoulam RPacher P. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol. 2010 Dec 14;56(25):2115-25. doi: 10.1016/j.jacc.2010.07.033. https://www.ncbi.nlm.nih.gov/pubmed/21144973
  30. Jeremy R.JohnsonMB ChBaMaryBurnell-NugentMB BChirbDominiqueLossignolMB ChB, MRCG, DRCOGcElena DoinaGanae-MotanMDdRichardPottsBSc (Hons), MICReMarie T.FallonMB ChB, MD, FRCP (E), FRCP (Glasg)f Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain J Am Coll Cardiol. 2010 Dec 14;56(25):2115-25. doi: 10.1016/j.jacc.2010.07.033. http://www.sciencedirect.com/science/article/pii/S0885392409007878
  31. Josée Guindon, Andrea G Hohmann The endocannabinoid system and cancer: therapeutic implication British Journal of Pharmacology First published: 12 July 2011  http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01327.x/full
  32. Blessing EMSteenkamp MMManzanares JMarmar CR. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015 Oct;12(4):825-36. doi: 10.1007/s13311-015-0387-1. https://www.ncbi.nlm.nih.gov/pubmed/26341731
  33. El-Alfy, Abir T, et al, “Indirect modulation of the endocannabinoid system by specific fractions of nutmeg total extract,” Pharmaceutical Biology, 2016.
  34. John M. McPartland, Geoffrey W. Guy, Vincenzo Di Marzo; Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System PLoS One. 2014; 9(3): e89566. Published online 2014 Mar 12. doi:  10.1371/journal.pone.0089566
  35. Nora D. Volkow, Director, National Institute on Drug AbuseSenate Caucus on International Narcotics ControlTestimony to Congress, The Biology and Potential Therapeutic Effects of Cannabidiol; June 24, 2015
  36. Nandini Acharya, Sasi Peukonda, Tatiana Shcheglove, Adam Hagymasi, Sreyashi Basu, Pramod Srivastava. Endocannabinoid system acts as a regulator of immune homeostasis in the gut, Proceedings of the Natioanl Academy of Sciences of the United States of America.  March 27, 2017,    vol. 114 no. 19 5005–5010, doi: 10.1073/pnas.1612177114
  37. García C, Palomo-Garo C, García-Arencibia M, Ramos J, Pertwee R, Fernández-Ruiz J. Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson’s disease. British Journal of Pharmacology. 2011;163(7):1495-1506. doi:10.1111/j.1476-5381.2011.01278.x.
  38. Martín-Moreno AM, Reigada D, Ramírez BG, et al. Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease. Molecular Pharmacology. 2011;79(6):964-973. doi:10.1124/mol.111.071290.
  39. Das RK, Kamboj SK, Ramadas M, Yogan K, Gupta V, Redman E, Curran HV, Morgan CJ. Cannabidiol enhances consolidation of explicit fear extinction in humans. 
    Psychopharmacology (Berl). 2013 Apr;226(4):781-92. doi: 10.1007/s00213-012-2955-y. Epub 2013 Jan 10
  40. Neelakantan H, Tallarida RJ, Reichenbach ZW, Tuma RF, Ward SJ, Walker EA.  Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice. 
    Behav Pharmacol. 2015 Apr;26(3):304-14
  41. Xiong W, Cui T, Cheng K, Yang F, Chen SR, Willenbring D, Guan Y, Pan HL, Ren K, Xu Y, Zhang L.Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.  J Exp Med. 2012 Jun 4;209(6):1121-34. doi: 10.1084/jem.20120242. Epub 2012 May 14.
  42. Bergamaschi MM, Queiroz RH, Chagas MH, de Oliveira DC, De Martinis BS, Kapczinski F, Quevedo J, Roesler R, Schröder N, Nardi AE, Martín-Santos R, Hallak JE, Zuardi AW, Crippa JA. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.  Neuropsychopharmacology. 2011 May;36(6):1219-26.
  43. Chakravarti B, Ravi J, Ganju RK. Cannabinoids as therapeutic agents in cancer: current status and future implications. Oncotarget. 2014;5(15):5852-5872.